Footnotes

• Twitter @ykalmutawa

• Contributors All the authors have contributed substantially to the planning, conducting and reporting of the submitted work.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent for publication Not required.

• Ethics approval Ethical approval has been obtained for all clinical studies reported in this manuscript.

• Provenance and peer review Not commissioned; externally peer reviewed.