Footnotes

• Contributors GC, JCM and DK planned the pilot infrastructure and wrote the manuscript. RHS and JD provided expert support and review of the manuscript. JCM is responsible for the overall content.

• Funding GC is supported by the National Institute for Health Research Rare Diseases Translational Research Collaboration (NIHR RD-TRC) and by the NIHR University College London Hospitals Biomedical Research Centre. JCM is directly and indirectly supported by the University College London Hospitals NIHR Biomedical Research Centre and Biomedical Research Unit at Barts Hospital, respectively. This cloud-based EDC pilot has been funded by Barts Charity Grants #MGU0305 and #1107/2356/MRC0140 to GC and JCM.

• Disclaimer The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

• Competing interests DK is the Chief Executive Officer of the AIMES Grid Service Providers, a commercial data centre service provider based in the North West of England.

• Provenance and peer review Not commissioned; externally peer reviewed.