Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Amyotrophic lateral sclerosis is a progressive neuromuscular disease characterized by both
lower motor neuron and upper motor neuron dysfunction. Although clinical presentations …

Background and Purpose—Carotid web (CW) is a rare form of focal fibromuscular dysplasia
defined as an abnormal shelf-like projection of intimal fibrous tissue into the carotid bulb. It is …

The cardiac ryanodine receptor (RyR2) governs the release of Ca2+ from the sarcoplasmic
reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to …

The design and synthesis of protein-like polymers is a fundamental challenge in materials
science. A biomimetic approach is to explore the impact of monomer sequence on non …

Ventricular tachycardia (VT) is the leading cause of sudden death, and the cardiac
ryanodine receptor (RyR2) is emerging as an important focus in its pathogenesis. RyR2 …

We present the results of a comprehensive Keck/DEIMOS spectroscopic survey of the ultra-
faint Milky Way satellite galaxy Segue 1. We have obtained velocity measurements for …

MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution
of specific miRNAs to the development and function of different neuronal populations is still …

Background Rilzabrutinib, an oral, reversible covalent inhibitor of Bruton's tyrosine kinase,
may increase platelet counts in patients with immune thrombocytopenia by means of dual …

Cyclic di-adenosine monophosphate (c-di-AMP) is a broadly conserved second messenger
required for bacterial growth and infection. However, the molecular mechanisms of c-di-AMP …