User profiles for "author:Gerard Sheehan"

Gerard Sheehan

Maynooth University
Verified email at mu.ie
Cited by 907

Innate humoral immune defences in mammals and insects: The same, with differences?

G Sheehan, A Garvey, M Croke, K Kavanagh - Virulence, 2018 - Taylor & Francis
The insect immune response demonstrates many similarities to the innate immune response
of mammals and a wide range of insects is now employed to assess the virulence of …

Immune priming: the secret weapon of the insect world

G Sheehan, G Farrell, K Kavanagh - Virulence, 2020 - Taylor & Francis
Insects are a highly successful group of animals that inhabit almost every habitat and
environment on Earth. Part of their success is due to a rapid and highly effective immune …

[HTML][HTML] Galleria mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions

M Piatek, G Sheehan, K Kavanagh - Antibiotics, 2021 - mdpi.com
Larvae of the greater wax moth, Galleria mellonella, are a convenient in vivo model for
assessing the activity and toxicity of antimicrobial agents and for studying the immune …

Increased platelet reactivity in HIV-1–infected patients receiving abacavir-containing antiretroviral therapy

CS Satchell, JA O'Halloran, AG Cotter… - Journal of Infectious …, 2011 - academic.oup.com
Background. Current or recent use of abacavir for treating human immunodeficiency virus
type 1 (HIV-1) infection has been associated with increased rates of myocardial infarction …

[HTML][HTML] The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest

K Kavanagh, G Sheehan - Journal of Fungi, 2018 - mdpi.com
The immune system of insects and the innate immune response of mammals share many
similarities and, as a result, insects may be used to assess the virulence of fungal pathogens …

Analysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans

G Sheehan, K Kavanagh - Virulence, 2018 - Taylor & Francis
Galleria mellonella larvae were administered an inoculum of Candida albicans and the
response to infection over 24 hours was monitored. The yeast cell density in infected larvae …

Investigating the effect of antiretroviral switch to tenofovir alafenamide on lipid profiles in people living with HIV

A Lacey, S Savinelli, EA Barco, A Macken, AG Cotter… - Aids, 2020 - journals.lww.com
Background: Whilst reporting improved renal and bone safety profiles, studies have noted
changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral …

Seizure with CSF lymphocytosis as a presenting feature of COVID-19 in an otherwise healthy young man

S Lyons, B O'Kelly, S Woods, C Rowan… - … -European Journal of …, 2020 - seizure-journal.com
A 20-year old previously well man was brought to hospital following a seizure. For three
days he had complained of myalgia, lethargy and fever. On attempting to get out of bed at …

Utilization of Galleria mellonella larvae to characterize the development of Staphylococcus aureus infection

G Sheehan, A Dixon, K Kavanagh - Microbiology, 2019 - microbiologyresearch.org
Staphylococcus aureus is a human opportunistic pathogen that causes a wide range of
superficial and systemic infections in susceptible patients. Here we describe how an …

UtilisingGalleria mellonella larvae for studying in vivo activity of conventional and novel antimicrobial agents

M Piatek, G Sheehan, K Kavanagh - Pathogens and Disease, 2020 - academic.oup.com
The immune response of insects displays many structural and functional similarities to the
innate immune response of mammals. As a result of these conserved features, insects may …