Characteristics of early-onset vs late-onset colorectal cancer: a review
R Collaborative, AM Zaborowski, A Abdile… - JAMA …, 2021 - jamanetwork.com
Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease …
globally, the reasons for which are unclear. It appears to represent a unique disease …
[HTML][HTML] The management of Peutz–Jeghers syndrome: European hereditary tumour group (EHTG) guideline
A Wagner, S Aretz, A Auranen, MJ Bruno… - Journal of clinical …, 2021 - mdpi.com
The scientific data to guide the management of Peutz–Jeghers syndrome (PJS) are sparse.
The available evidence has been reviewed and discussed by diverse medical specialists in …
The available evidence has been reviewed and discussed by diverse medical specialists in …
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
N Hearle, V Schumacher, FH Menko, S Olschwang… - Clinical Cancer …, 2006 - AACR
Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established,
data on the spectrum of tumors associated with the disease and the influence of germ-line …
data on the spectrum of tumors associated with the disease and the influence of germ-line …
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …
cancer and various other cancers, and is caused by a mutation in one of the mismatch repair …
The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
A Ahadova, TT Seppälä, C Engel… - … journal of cancer, 2021 - Wiley Online Library
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes,
are at increased risk of developing malignancies, in particular colorectal cancer (CRC) …
are at increased risk of developing malignancies, in particular colorectal cancer (CRC) …
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome …
P Møller, T Seppälä, I Bernstein, E Holinski-Feder… - Gut, 2017 - gut.bmj.com
Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
been subject to bias, partly through reliance on retrospective studies. We sought to establish …
[HTML][HTML] Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
syndrome and result in different but imprecisely known cancer risks. This study aimed to …
Familial endometrial cancer in female carriers of MSH6 germline mutations
MSH6 germline mutations 142 nature genetics• volume 23• october 1999 gressive muscular
dystrophy. This mouse will become a useful animal model for studying the …
dystrophy. This mouse will become a useful animal model for studying the …
Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444
R Caspari, S Olschwang, W Friedl… - Human Molecular …, 1995 - academic.oup.com
An earlier study has shown that FAP patients with mutations in codons 136–302 of the APC
gene do not develop congenital hypertrophy of the retinal pigment epithelium (CHRPE) …
gene do not develop congenital hypertrophy of the retinal pigment epithelium (CHRPE) …
[HTML][HTML] Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
Background Observational and epidemiologic data indicate that the use of aspirin reduces
the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome …
the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome …