Over the past two decades there has been considerable progress with the evaluation and
management of infants with an inconclusive diagnosis following Newborn Screening (NBS) …

OBJECTIVES: To determine the prevalence of bronchiectasis in young children with cystic
fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of …

Rationale: Better understanding of evolution of lung function in infants with cystic fibrosis
(CF) and its association with pulmonary inflammation and infection is crucial in informing …

Rationale: Progressive lung damage in cystic fibrosis (CF) starts in infancy, and early
detection may aid preventative strategies. Objectives: To measure lung function in infants …

The diagnosis of cystic fibrosis (CF) has traditionally relied on the presence of clinical
features of the disease. Today, diagnosis through newborn screening (NBS) is becoming the …

Background Newborn screening (NBS) for cystic fibrosis (CF) is a well-established public
health strategy with international standards. The aim of this study was to provide an update …

Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …

Background Tezacaftor–ivacaftor is an approved cystic fibrosis transmembrane conductance
regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated …

Rationale: Patient registries have the potential to collect and analyze high-quality
postauthorization data on new medicines. Objectives: We used cystic fibrosis (CF) registry …

Background Molecular techniques have uncovered vast numbers of organisms in the cystic
fibrosis (CF) airways, the clinical significance of which is yet to be determined. The aim of …