Computational omics methods packaged as software have become essential to modern
biological research. The increasing dependence of scientists on these powerful software …

Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective
treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable …

A phosphoramidate prodrug of 2′-deoxy-2′-α-fluoro-β-C-methyluridine-5′-
monophosphate, PSI-7851, demonstrates potent anti-hepatitis C virus (HCV) activity both in …

ABSTRACT PSI-7977, a prodrug of 2′-F-2′-C-methyluridine monophosphate, is the
purified diastereoisomer of PSI-7851 and is currently being investigated in phase 3 clinical …

The hepatitis C virus (HCV) NS5B RNA polymerase facilitates the RNA synthesis step during
the HCV replication cycle. Nucleoside analogs targeting the NS5B provide an attractive …

Eosinophilic esophagitis (EoE) is an antigen-mediated chronic T helper type 2 (Th2)-
associated inflammatory disorder that has emerged in the last three decades as an …

The hepatitis B virus (HBV) core protein is essential for HBV replication and an important
target for antiviral drug discovery. We report the first, to our knowledge, high-resolution …

The replication of the hepatitis C viral (HCV) genome is accomplished by the NS5B RNA-
dependent RNA polymerase (RdRp), for which mechanistic understanding and structure …

Mutations were introduced into the NS3 helicase region of a hepatitis C virus (HCV) Con1
subgenomic replicon to ascertain the role of the helicase in viral replication. One new …

The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life
cycle, and antiviral agents that target the core protein are being developed. Capsid …