Major themes and subthemes extracted from the included literature
| Major themes | Subthemes |
| Affordability | Payer's budget |
| Therapy cost/price | |
| Therapy payment/reimbursement | |
| Assessment of value | Criteria |
| Non-patient related health benefit | |
| Patient-related health benefits | |
| Development of therapy | Intellectual property |
| Manufacturing | |
| Non-clinical | |
| Positioning | |
| Resources | |
| Ethical/social factors | Patient's convictions |
| Patient's perception | |
| Socioeconomical | |
| Evidence generation | Trial design |
| Trial conduct | |
| Trial outcomes | |
| Postauthorisation | |
| Operational implementation | Infrastructures |
| Patient burden | |
| Healthcare professionals | |
| Regulatory hurdles | Marketing authorisation application process |
| Quality standards | |
| Pricing regulations | |
| Parallel access |