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Administration of aspirin tablets using a novel gel-based swallowing aid: an open-label randomised controlled cross-over trial
  1. David John Wright1,
  2. John F Potter2,
  3. Allan Clark2,
  4. Annie Blyth2,
  5. Vivienne Maskrey2,
  6. Giovanna Mencarelli3,
  7. Sarah O Wicks4,
  8. Duncan Q M Craig5
  1. 1Pharmacy, University of East Anglia, Norwich, UK
  2. 2Medicine, University of East Anglia, Norwich, UK
  3. 3University of Bath, Bath, UK
  4. 4Department of Pharmacy, Health and Well-Being, University of Sunderland, Sunderland, UK
  5. 5School of Pharmacy, University College London, London, UK
  1. Correspondence to David John Wright, Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK; d.j.wright{at}uea.ac.uk

Footnotes

  • Contributors DJW and DQMC originated the idea for the gel, were coapplicants for the MRC funding and were responsible for managing the project. GM and SOW were responsible for gel development and testing in vitro. AB and VM were responsible for gel testing in vivo. AC provided statistical input at all stages of the study. AB, VM, SOW, DJW and JFP were responsible for development of the clinical trial protocol and JFP was the principal investigator responsible for management of the trial at the site. All authors contributed to the writing of the article and provided feedback on the different iterations.

  • Funding The study was funded by the Medical Research Council ‘Developmental Pathway Funding Scheme’ (grant reference: G902184).

  • Competing interests DJW undertakes consultancy work for and currently holds a research grant from Rosemont Pharmaceuticals who manufactures liquid medicines.

  • Patient consent for publication Not required

  • Ethics approval MHRA Device (CI/2012/0030 SMART Swallowing Aid) and NHS Research Ethics Committee approvals (Cambridge Central NRES Committee, East of England 14/EE/0156) were obtained prior to commencement of the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data are available upon reasonable request.

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Footnotes

  • Contributors DJW and DQMC originated the idea for the gel, were coapplicants for the MRC funding and were responsible for managing the project. GM and SOW were responsible for gel development and testing in vitro. AB and VM were responsible for gel testing in vivo. AC provided statistical input at all stages of the study. AB, VM, SOW, DJW and JFP were responsible for development of the clinical trial protocol and JFP was the principal investigator responsible for management of the trial at the site. All authors contributed to the writing of the article and provided feedback on the different iterations.

  • Funding The study was funded by the Medical Research Council ‘Developmental Pathway Funding Scheme’ (grant reference: G902184).

  • Competing interests DJW undertakes consultancy work for and currently holds a research grant from Rosemont Pharmaceuticals who manufactures liquid medicines.

  • Patient consent for publication Not required

  • Ethics approval MHRA Device (CI/2012/0030 SMART Swallowing Aid) and NHS Research Ethics Committee approvals (Cambridge Central NRES Committee, East of England 14/EE/0156) were obtained prior to commencement of the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Data are available upon reasonable request.

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