Footnotes

• Correction notice This article has been corrected since it published Online First. The authors noticed miscellaneous errors which have been rectified now.

• Contributors PB planned the manuscript with AB, wrote the opening of manuscript, contributed text associated with the figure, contributed to and approved all draft and final revisions and is the guarantor. DL conducted the reference review, wrote summaries of references, prepared the Definitions Box and Reference section, and contributed to and approved all draft and final revisions. AB planned the manuscript with PB, wrote the conclusion of manuscript, prepared the figure, participated in review and revision of drafts, and contrtibuted to and approved all draft and final revisions.

• Funding This project was supported by the National Center for Advancing Translational Sciences, National Institutes of Health (Award No TL1TR001062).

• Competing interests PB retired from Genzyme/Sanofi in April 2017, and is presently Director of the MD/MBA Program and Assistant Professor in the Department of Public Health and Community Medicine in Tufts University School of Medicine. AB is a full-time entrepreneur in the area of generic oncology drugs, and adjunct lecturer in the Department of Public Health and Community Medicine in Tufts University School of Medicine. DL is an MD/MBA candidate (Class of 2019) in Tufts University School of Medicine. The authors do not have any other financial interests that could create a potential conflict of interest or the appearance of one regarding this work.

• Patient consent for publication Not required.

• Provenance and peer review Not commissioned; externally peer reviewed.