User profiles for "author:Frans Henskens"

Frans Henskens

Conjoint Professor, School of Medicine & Public Health, University of Newcastle
Verified email at newcastle.edu.au
Cited by 28978

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

V Trubetskoy, AF Pardiñas, T Qi, G Panagiotaropoulou… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

BJ Vilhjálmsson, J Yang, HK Finucane, A Gusev… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

CR Marshall, DP Howrigan, D Merico… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …

TGM Van Erp, E Walton, DP Hibar, L Schmaal… - Biological …, 2018 - Elsevier
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

A Gusev, SH Lee, G Trynka, H Finucane… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to …

[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

J Radua, E Vieta, R Shinohara, P Kochunov, Y Quidé… - Neuroimage, 2020 - Elsevier
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

G Ni, J Zeng, JA Revez, Y Wang, Z Zheng, T Ge… - Biological …, 2021 - Elsevier
Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …

The australian eeg database

M Hunter, RLL Smith, W Hyslop… - Clinical EEG and …, 2005 - journals.sagepub.com
The Australian EEG Database is a web-based de-identified searchable database of 18,500
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …

[PDF][PDF] Estimation of genetic correlation via linkage disequilibrium score regression and genomic restricted maximum likelihood

G Ni, G Moser, S Ripke, BM Neale, A Corvin… - The American Journal of …, 2018 - cell.com
Genetic correlation is a key population parameter that describes the shared genetic
architecture of complex traits and diseases. It can be estimated by current state-of-art …

White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs

P Klauser, ST Baker, VL Cropley… - Schizophrenia …, 2017 - academic.oup.com
White matter abnormalities associated with schizophrenia have been widely reported,
although the consistency of findings across studies is moderate. In this study, neuroimaging …