User profiles for "author:Frans Henskens"
Frans HenskensConjoint Professor, School of Medicine & Public Health, University of Newcastle Verified email at newcastle.edu.au Cited by 28978 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …
[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …
fully understood, despite hundreds of published structural brain imaging studies. This study …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to …
genome-wide association studies (GWASs) of complex disease, but their contributions to …
[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
The australian eeg database
M Hunter, RLL Smith, W Hyslop… - Clinical EEG and …, 2005 - journals.sagepub.com
The Australian EEG Database is a web-based de-identified searchable database of 18,500
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …
[PDF][PDF] Estimation of genetic correlation via linkage disequilibrium score regression and genomic restricted maximum likelihood
Genetic correlation is a key population parameter that describes the shared genetic
architecture of complex traits and diseases. It can be estimated by current state-of-art …
architecture of complex traits and diseases. It can be estimated by current state-of-art …
White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs
White matter abnormalities associated with schizophrenia have been widely reported,
although the consistency of findings across studies is moderate. In this study, neuroimaging …
although the consistency of findings across studies is moderate. In this study, neuroimaging …