User profiles for "author:Alex Semprini"

Alex Semprini

Deputy Director, Medical Research Institute of New Zealand
Verified email at mrinz.ac.nz
Cited by 1594

Risk factors for asthma: is prevention possible?

R Beasley, A Semprini, EA Mitchell - The Lancet, 2015 - thelancet.com
Asthma is one of the most common diseases in the world, resulting in a substantial burden of
disease. Although rates of deaths due to asthma worldwide have reduced greatly over the …

Optimal asthma control: time for a new target

R Beasley, I Braithwaite, A Semprini… - American Journal of …, 2020 - atsjournals.org
The stepwise approach to pharmacological treatment in adult asthma mandates that asthma
treatment is progressively stepped up to achieve symptom control and reduce the risk of …

Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group …

ID Pavord, M Holliday, HK Reddel… - The Lancet …, 2020 - thelancet.com
Background Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are
associated with important outcomes in mild asthma is unclear. In this prespecified subgroup …

Cannabis in palliative care: a systematic review of current evidence

M Doppen, S Kung, I Maijers, M John, H Dunphy… - Journal of Pain and …, 2022 - Elsevier
Context Palliative care aims to improve the quality of life in patients with incurable illness.
Medicinal cannabis (MC) has been used in the palliative care setting to address multiple …

[HTML][HTML] An Aotearoa New Zealand survey of the impact and diagnostic delay for endometriosis and chronic pelvic pain

J Tewhaiti-Smith, A Semprini, D Bush, A Anderson… - Scientific reports, 2022 - nature.com
Chronic pelvic pain (CPP) causes important negative effects on quality of life. Endometriosis
is the most common cause of CPP in females, and diagnostic delay is over six years …

[HTML][HTML] Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial

A Semprini, J Singer, I Braithwaite, N Shortt… - BMJ open, 2019 - bmjopen.bmj.com
Objective To compare New Zealand medical grade kanuka honey with topical aciclovir for
the treatment of herpes simplex labialis. Design Prospective parallel randomised controlled …

How big is your bubble? Characteristics of self-isolating household units ('bubbles') during the COVID-19 Alert Level 4 period in New Zealand: A cross-sectional …

N Kearns, N Shortt, C Kearns, A Eathorne, M Holliday… - BMJ open, 2021 - bmjopen.bmj.com
Objective To characterise the self-isolating household units (bubbles) during the COVID-19
Alert Level 4 lockdown in New Zealand. Design, setting and participants In this cross …

ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma

R Beasley, I Braithwaite, A Semprini… - European …, 2020 - Eur Respiratory Soc
A stepwise approach to the pharmacological treatment of asthma is a key feature of current
asthma guidelines [1–4]. Through algorithms, treatment intensity is “stepped up” to obtain …

[HTML][HTML] The Anti-Inflammatory Reliever (AIR) Algorithm Study: a protocol for a single-group study of an AIR stepwise approach to the treatment of adult asthma

P Bruce, L Hatter, C Houghton, C Kearns… - ERJ Open …, 2023 - Eur Respiratory Soc
Background The stepwise approach to long-term asthma management, which traditionally
incorporates short-acting β2-agonist reliever therapy, has been a core feature of asthma …

Type 2 biomarkers and prediction of future exacerbations and lung function decline in adult asthma

R Semprini, M Williams, A Semprini, A McDouall… - The Journal of Allergy …, 2018 - Elsevier
Background Type 2 biomarkers that predict both likelihood of future severe exacerbations
and response to mAb therapy in asthma would be useful clinically in identifying patients both …