First author | Primary outcome measure | Evaluation study design | Primary data collection method | Comparator outcomes | Outcomes of top-ranked submission | Summary findings | Study quality Scale: 0–10 |
Chansrichavala et al45 | Opinion regarding the potential use of videos to raise public awareness of melioidosis | Qualitative focus group discussion | Focus group audio recording | – | – | Top 12 video submissions had strong potential to increase public awareness of melioidosis | 9.5 |
Costello and Stolovitzky6 | Predictive accuracy of cancer drug sensitivity | Retrospective observational cohort and cross-validation of predictive algorithms | Clinical biomarkers | 0.500 | 0.583 | Finalist algorithm predicted cancer drug sensitivity significantly more accurately than random assignment (p<0.0001) | 8.1 |
Costello and Stolovitzky6 | Identification of causal gene mutations and innovative clinical diagnostic protocols | Individual patient genomic sequencing | Clinical biomarkers | NA | NA | Finalist team identified causal genetic mutation of a rare condition and submitted innovative protocols in genome analysis, interpretation and reporting | 8.1 |
Küffner et al50 | Deviation of predictive algorithm of ALS disease progression from observed clinical outcomes | Retrospective observational cohort & cross-validation of predictive algorithms | Clinical biomarkers and behavioural indicators | 0.559 | 0.544 | Finalist algorithm predicted ALS disease progression more accurately than benchmark standard, but not significantly (p>0.05). Improvement in prediction could potentially reduce size and cost of future clinical trials. | 9.4 |
Lakhani et al52 | Speed and accuracy of genomic analysis | Cross-validation of analytical algorithms | Clinical biomarkers | 15 616 s; 72% accuracy | 16 s; 80% accuracy | Finalist algorithm analysed genomes faster and more accurately than industry standard. | 9.4 |
Zhang et al43 | Proportion who had HIV test after 3 months postintervention | Randomised control trial | Survey | 0.35 | 0.37 | HIV test promotion finalist video performed as well as professionally created social marketing video (p>0.05) and had greater cost-savings. | 9.4 |
Tang et al44 | Proportion who had engaged in condomless sex after 3 months postintervention | Randomised control trial | Survey | 0.336 | 0.323 | Crowdsourced sexual health image intervention achieved non-inferiority at 3 months (p>0.05) and had greater cost-savings compared with conventional social marketing alternative. | 9.4 |
ALS, Amyotrophic Lateral Sclerosis.