Table 1

Major inclusion and exclusion criteria

Inclusions	Exclusions
▸ Adults of either gender from 22 to 80 years of age, inclusive ▸ Grade 2 or more functional MR per 2D or 3D transthoracic echocardiography ▸ Symptomatic (NYHA Class ≥II) heart failure patient with MR ▸ Participant undergoing concomitant CABG or aortic valve surgery ▸ Normal mitral valve leaflets	▸ NYHA Class IV after optimal medical therapy ▸ Structural abnormality of the mitral valve ▸ High pulmonary artery pressures ▸ Severe diastolic dysfunction of the left ventricle on echocardiography ▸ Transmural MI within 30 days of enrolment; non-ST segment elevation MI within 7 days of enrolment ▸ Previous mitral valve surgery, CABG or other previous cardiac surgery that would preclude proper placement of the BACE ▸ Chronic renal failure requiring dialysis

Inclusions

Exclusions

▸ NYHA Class IV after optimal medical therapy
▸ Structural abnormality of the mitral valve
▸ High pulmonary artery pressures
▸ Severe diastolic dysfunction of the left ventricle on echocardiography
▸ Transmural MI within 30 days of enrolment; non-ST segment elevation MI within 7 days of enrolment
▸ Previous mitral valve surgery, CABG or other previous cardiac surgery that would preclude proper placement of the BACE
▸ Chronic renal failure requiring dialysis