RT Journal Article
SR Electronic
T1 Characterisation of the aortic pulse profile of a radial artery applanation tonometry device in patients with aortic stenosis
JF BMJ Innovations
JO BMJ Innov
FD All India Institute of Medical Sciences
SP 24
OP 28
DO 10.1136/bmjinnov-2017-000210
VO 4
IS 1
A1 Nicholas Ngiam
A1 Xiayan Shen
A1 Benjamin Yong-Qiang Tan
A1 Sachiko Oinuma
A1 Glenn KM Lee
A1 William KF Kong
A1 Kian-Keong Poh
YR 2018
UL http://innovations.bmj.com/content/4/1/24.abstract
AB Background Aortic stenosis (AS) is commonly associated with myocardial and systemic arterial dysfunction. We use a radial artery applanation tonometry (B-Pro) device to characterise the arterial pulse profile of patients with AS and compare them against controls.Methods The B-Pro device was applied on the left radial artery of 117 consecutive patients, where 21 patients had AS. Baseline clinical and echocardiographic characteristics were compared. Differences in arterial pulse pressure profile were quantified by means of univariate and multivariable analyses.Results The group with AS was older (74±14 vs 62±14 years, P<0.001) and had fewer males (38% vs 65%, P=0.025), while other baseline comorbidities were similar. From the arterial pulse profile, a higher systolic peak time (202±45 vs 152±49 ms, P<0.001), lower systolic upstroke gradient (0.35±0.10 vs 0.42±0.14 mm Hg/ms, P=0.022) and longer systolic component of the cardiac cycle (43%±7% vs 39%±5%, P=0.001) were independently associated with AS.Conclusion The B-Pro device allows for real-time microscopic arterial pulse waveform analysis. There are significant differences between the pulse profiles of patients with AS and controls. The prognostic implications of these differences warrant further study.