PT  - JOURNAL ARTICLE
AU  - Nicholas Ngiam
AU  - Xiayan Shen
AU  - Benjamin Yong-Qiang Tan
AU  - Sachiko Oinuma
AU  - Glenn KM Lee
AU  - William KF Kong
AU  - Kian-Keong Poh
TI  - Characterisation of the aortic pulse profile of a radial artery applanation tonometry device in patients with aortic stenosis
AID  - 10.1136/bmjinnov-2017-000210
DP  - 2018 Jan 01
TA  - BMJ Innovations
PG  - 24--28
VI  - 4
IP  - 1
4099  - http://innovations.bmj.com/content/4/1/24.short
4100  - http://innovations.bmj.com/content/4/1/24.full
SO  - BMJ Innov2018 Jan 01; 4
AB  - Background Aortic stenosis (AS) is commonly associated with myocardial and systemic arterial dysfunction. We use a radial artery applanation tonometry (B-Pro) device to characterise the arterial pulse profile of patients with AS and compare them against controls.Methods The B-Pro device was applied on the left radial artery of 117 consecutive patients, where 21 patients had AS. Baseline clinical and echocardiographic characteristics were compared. Differences in arterial pulse pressure profile were quantified by means of univariate and multivariable analyses.Results The group with AS was older (74±14 vs 62±14 years, P<0.001) and had fewer males (38% vs 65%, P=0.025), while other baseline comorbidities were similar. From the arterial pulse profile, a higher systolic peak time (202±45 vs 152±49 ms, P<0.001), lower systolic upstroke gradient (0.35±0.10 vs 0.42±0.14 mm Hg/ms, P=0.022) and longer systolic component of the cardiac cycle (43%±7% vs 39%±5%, P=0.001) were independently associated with AS.Conclusion The B-Pro device allows for real-time microscopic arterial pulse waveform analysis. There are significant differences between the pulse profiles of patients with AS and controls. The prognostic implications of these differences warrant further study.